The 25-year-old suffered a hamstring injury during Senegal's 2-0 African Cup of Nations qualifier win over Namibia.
Villa travel to the King Power Stadium in the Barclays Premier League on Sunday with Gueye a doubt but boss Tim Sherwood hopes to have him available.
He said: "He was the one player we didn't want to lose because he's playing so well.
"He picked up a hamstring injury in the 75th minute of the game so I'm hoping that it's just fatigue.
"Normally when you pull a hamstring it's early in the game.
"The physios are assessing him so if it is fatigue, he's got a chance
He's a tough guy
"When we cut him, I think wires come out of him so we've got a chance
It can't be quick enough for him.
"He loves the hustle and bustle and the physical side of the game
He's a huge presence and a driving force."
Gueye joined from Lille in the summer and has replaced Fabian Delph in midfield after the England star moved to Manchester City for £8million and Sherwood has been impressed with his impact.
He said: "When you look at him you might not think he has the physical presence, but he looks huge out there on the pitch
He changes size when he's on the pitch
He's a driving force.
"You are always going to miss a player of Fabian's quality, no point pretending otherwise."
Sherwood is hopeful Jack Grealish will be fit after an ankle problem but Jores Okore (knee) is out and Liverpool loanee Tiago Ilori is not match fit but Joleon Lescott could make his debut after signing from West Brom.
Source : PA
Source: PA