Ledley King's ongoing knee problem is likely to prevent the Tottenham captain from playing a second match in three days after featuring against FC Twente.Vedran Corluka and Sebastien Bassong will therefore be paired in central defence, while Benoit Assou-Ekotto could feature at left-back.
Aston Villa pair John Carew and Richard Dunne have recovered from back and knee injuries respectively.
Gabriel Agbonlahor misses out and must undergo a minor groin operation.
Tottenham
Doubtful: King (knee)
Injured: Dawson (knee & ankle), Defoe (ankle), Gallas & Woodgate (both groin), Kaboul (hamstring), O'Hara (back)
Aston Villa
Injured: Agbonlahor (groin), Delph (knee), Weimann (ankle)
MATCH PREVIEW
Having given plenty against Twente, can Tottenham summon the energy to vanquish Villa and reassert their top-four credentials?
People are now looking at us after we've played our European games. The spotlight is on us and teams are waiting for us to slip up, saying we're the same old Tottenham. We don't want to be like that
Tottenham captain Ledley King
Spurs fans were singing in the rain during the midweek Champions League victory, but the club need to guard against a domestic damp squib.
Although the perception that Tottenham struggle in post-European matches is a little unfair, there is no denying they were laboured at home in defeat by Wigan and victory over Wolves.
Villa could be welcome opponents. They have only won this fixture once in a decade, and their new manager also has an unenviable record at White Hart Lane: Gerard Houllier's first ever Premier League away defeat came at Tottenham, in December 1998, and he has lost five of his six previous league visits.
Houllier has started his Villa reign with successive victories. The Frenchman has praised the character of the squad he inherited, and they will need to show plenty of that if they are to upset Spurs and Chelsea in their next two games.
MATCH FACTS
Head-to-head
• Villa's only win in their last 10 visits to White Hart Lane was a 2-1 victory in September 2008 (W1, D5, L4).
• Harry Redknapp is unbeaten in eight league matches against Aston Villa since his Portsmouth side lost 1-0 at Villa Park in March 2006.
Do you agree with Lawro's prediction?
Tottenham
• Spurs are attempting to avoid back-to-back league defeats for the first time in 11 months since losing at home to Stoke and away to Arsenal.
• They have earned eight points from six matches - four fewer than at the same stage last season.
• Tottenham have only been ahead at half time in one of their six league fixtures this season.
• They have conceded once in each of their last five league matches. This is their longest run without a clean sheet since conceding in each of their opening six games last season.
Aston Villa
• Villa are vying for successive wins for the first time since winning three in a row in April.
• They have conceded 12 goals in their last four away matches.
• Emile Heskey has scored in back-to-back club appearances for the first time since April 2008. He has now scored four goals in his last five matches under Gerard Houllier.
• Ashley Young will be making his 150th Premier League appearance.
LEADING GOALSCORERS
Tottenham
Pavlyuchenko: 4 goals (1 league); Crouch: 4 goals (0 league)
Aston Villa
Downing: 3 goals (3 league); Heskey & A Young: 3 goals (1 league)
MATCH OFFICIALS
Referee: Mark Clattenburg
Assistant referees: Jake Collin & Scott Ledger
Fourth official: Stuart Attwell
LAST LEAGUE MATCH LINE-UPS
Tottenham (L0-1 v West Ham, a): Cudicini; Hutton, Corluka, Bassong, Bale, Lennon (Keane 66), Huddlestone, Jenas, Modric, Van der Vaart (Giovani 78), Crouch (Pavlyuchenko 80). Subs not used: Pletikosa, Palacios, Kranjcar, Sandro.
Aston Villa (W2-1 v Wolves, a): Friedel; L Young, Cuellar, Collins, Warnock, Albrighton (Agbonlahor 67), Reo-Coker, Petrov (Sidwell 86), Downing, A Young, Heskey. Subs not used: Guzan, Ireland, Davies, Bannan, Lichaj.
Source: BBC Sport
Source: BBC Sport