Reo-Coker even scored the winner in a 1-0 victory at Upton Park.
Most of the other Villa players have no experience of beating what is clearly their bogey team. Although United are undoubtedly very talented, Villa rarely even come close to defeating their old nemesis.
But, with the driving force of the real Reo, Nigel as oppose to Rio Ferdinand, who knows what could happen on Saturday.
England defender Ferdinand will take nothing for granted as he has the task of marking one of the country's hottest marksmen, Gabby Agbonlahor. Hopefully the pacy young striker will tie him up, so that the forward runs of Reo-Coker and Gareth Barry reap reward for O'Neill's men.
Villa were brilliant in the first 20 minutes against United earlier in the season and even grabbed an opener through Gabby Agbonlahor. Unfortunately it was the same old story as the Red Devils came back strongly and romped to a 4-1 win.
The Claret and Blue will hope to have John Carew available and if fit he will replace the out of sorts Luke Moore.
If Carew fails to make it, O'Neill may turn to diminuitive Scot Shaun Maloney as a partner for Agbonlahor.
United will welcome back Edwin Van Der Sar for the trip to Villa Park, where they have won on their last 10 visits in League and Cup.
Wayne Rooney also returns, but Carlos Tevez may miss out.
Reo-Coker and the boys will be out for revenge, and with the powerful midfield influence of the former England U21 captain Villa could just trouble United. Let's hope Nigel shows who is the real Rio!
Come on Villa!