Last season, Leicester City ruined the Claret and Blue's best chance of silverware and this time around it's QPR who are the party poopers.
A second half header for Damion Stewart was enough for victory as Villa failed to break down the London bus that stood in front of the away goalposts.
Martin O'Neill again chose to rest key players in the competition, a tactic which proved to be his downfall against the Foxes in the third round last year.
But, he will have been confident that a side containing the likes of Ashley Young, John Carew and skipper for the night Gareth Barry, would progress.
Unfortunately, if unusually, he was wrong.
It was a case of deja-vu and Villa's awful cup form continues.